Norwegian IBD Study Group

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Forskningsgrupper i Norge

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Oversikt

Vi ønsker å være en plattform som knytter sammen IBD-forskningsgrupper i Norge, både eksisterende og nye.

HELSE MØRE OG ROMSDAL

NTNU - Helse Midt Norge, Helse Nord-Trøndelag, Helse More og Rømsdal

HELSE BERGEN

Forskningsprofil Bergen/Haukeland Universitetssjukehus (HUS)

Ibsen III

IBSEN III - Inflammatorisk tarmsykdom i Sørøst-Norge

IBSEN III-prosjektet er en stor, populasjonsbasert, observasjonell og prospektiv studie som er designet for å besvare sentrale spørsmål om forekomst, behandling og oppfølging av pasienter med inflammatorisk tarmsykdom (IBD).

Helse Møre og Romsdal

NTNU - Helse Midt Norge, Helse Nord-Trøndelag, Helse More og Rømsdal

The Inflammatory bowel diseases research group (IBD) studies disease mechanisms in inflammatory bowel diseases, and aims to use this knowledge in clinical medicine.

Akershus universitetssykehus

Gastromedisinsk forskningsgruppe ved Akershus universitetssykehus

Gastromedisinsk forskningsgruppe er ledet av professor Jørgen Jahnsen. Gruppen består av 12 personer, åtte leger (en professor II, en 1.amanuensis, en postdoc, fem PhD-studenter) og fire studiesykepleiere.

Akershus universitetssykehus

Barnegastroenterologisk forskningsgruppe ved Akershus universitetssykehus

Barnegastroenterologisk forskningsgruppe arbeider med basalmedisinske og kliniske studier knyttet til mage-tarm- og tarmflora (mikrobiota). Hovedfokuset er inflammatorisk tarmsykdom (eng. IBD).

Helse Stavanger - Stavanger Universitetssykehus

Gastroenterologisk forskningsgruppe ved Stavanger universitetssjukehus

Gastroenterologisk forskningsgruppe arbeider med studier knyttet til mage-/tarm- og leversykdommer. Hovedfokuset er inflammatorisk tarmsykdom (eng. IBD).

Haukeland universitetssjukehus

Forskningsprofil Bergen/Haukeland Universitetssjukehus (HUS)

Gastroenterologisk seksjon på HUS har mange ulike forskningsgrupper med ulike interesseområder som bl.a fokuserer på irritabel tarm, bukspyttkjertel avansert endoskopi og inflammatorisk tarm (IBD).

Oslo Universitet Sykehus | Logo

Inflammatory bowel disease research group

The focus for the inflammatory bowel disease (IBD) research group is clinical epidemiology, prognostic research and patient-reported outcomes research within IBD (Crohn’s disease and ulcerative colitis).

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Helse Møre og Romsdal

NTNU - Helse Midt Norge, Helse Nord-Trøndelag, Helse More og Rømsdal

IBD Research Group

The Inflammatory bowel diseases research group (IBD) studies disease mechanisms in inflammatory bowel diseases, and aims to use this knowledge in clinical medicine.

The group’s work is based on a large, still expanding research biobank with tissue samples and blood fractions collected over several years. Research is done using all standard laboratory methods and cutting-edge techniques such as e.g advanced histological imaging, human organoids for mechanistic studies and transcriptomics/genomics.

Example projects are the effect of genetics on the inflammatory process, how hypoxia influences the epithelial barrier, the action and regulation of mucosal antimicrobial peptides and how the diffuse neuroendocrine system interacts with immune signaling in inflammatory bowel diseases. This work is done in collaboration with researchers at NTNU, researchers and clinicians at hospitals within the Central Norway Regional Health Authority, and several national and international partners.

The IBD research group is a translational environment, engaging clinicians and biologists in patient-centered research from bedside to the laboratory bench.

The IBD group receives large grants from The Liaison Committee for education, research and innovation in Central Norway. Some of the members in the research group are part of Centre of molecular inflammation research (CEMIR) at the Department of Clinical and Molecular Medicine (IKOM), the Inflammatory bowel diseases research group.

The research group has close collaboration with the hospitals in the region through the Clinical Academic Group (CAG) Precision medicine in inflammatory bowel disease.

LINK: https://www.ntnu.edu/ikom/inflamboweldiseas#/view/about

CAG IBD – Precision medicine in inflammatory bowel disease

The main goal of a CAG is to bring the research closer to the patients, and produce «patient-centered» results to be quickly implemented in the clinic.

A CAG is an Academic Clinical Research Group, which consists of researchers and clinicians from different universities and hospitals. The aim is to solve a concrete health problem and increase the quality within the field of clinical practice. CAG provides a strong professional network across healthcare settings from universities to everyday clinical work.

The first CAGs in Norway were established at the initiative of the Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, according to a Danish model. The CAGs are supported both by the university (NTNU) and by the health trust (Central Norway Regional Health Authority), and intend to build strong clinical-academic interdisciplinary competence.

Current challenges in IBD

Diagnosis, treatment and multidisciplinary care of patients with IBD (ulcerative colitis and Crohn´s disease) is an important part of the activity of gastroenterology departments. Most patients are diagnosed with IBD at a young age and this means, for many, decades of active disease and treatment. In addition, a well-known problem in the clinic is that the course of the disease and the effect of treatments are difficult to predict. This heterogeneity is also a challenge in IBD research. 

Our research team will use the CAG award to contribute to the development of precision medicine (individualized approach) for IBD patients by continuing our translational research on carefully controlled patient material.

Clinical collaboration

CAG-IBD will contribute to unite gastroenetrology departments in the region and experienced IBD researchers in one joint group for patient-focused translation research with the National Patient Organization for Digestive Diseases (LMF) as support. 

Clinical collaboration

CAG-IBD will contribute to unite gastroenetrology departments in the region and experienced IBD researchers in one joint group for patient-focused translation research with the National Patient Organization for Digestive Diseases (LMF) as support. 

Our goal

From the clinical perspective, the goal is that all departments establish standardized diagnostics, follow-up and treatment decision protocols for patients with IBD. The clinical process will train clinicians in evidence-based gastroenterology, and bring non-university hospitals towards cutting-edge IBD diagnostics and treatment. In parallel, the project seeks to train IBD nurses to ensure optimal patient care.

We will collect clinical information and biological samples from diagnosis and at set times throughout the course of the disease. The project will create a particularly well-controlled, longitudinal biobank for IBD research aimed at clarifying prognostic factors, predicting treatment response and understanding disease mechanisms. This cohort thus meets the widely acknowledged need for precisely characterized clinical and biological research material, and will create opportunities for research collaboration both nationally and internationally.

1.Histopathology Unit

The Histopathology Unit explores the use of histological indexing and both traditional and advanced molecular pathology to identify patient subgroups, and integrates this with clinical data, genetic/genomics and patient-derived ex vivo studies. This will facilitate in-depth understanding of underlying biological differences and disease heterogeneity.

As part of this, we collaborate with Dept. of Pathology, St. Olavs Hospital, to develop the use of digital computational pathology to enable automated and more accurate image analysis of tissue samples for research and in the clinic. Our aim is to identify clinically relevant histopathological markers and provide pathologists with complementary tools to help release the highly unexplored potential for more precise and personalized diagnostics in IBD.

Objectives for ongoing research activities:

  1. Correlate histological indexing with endoscopic and clinical parameters and determine its prognostic and predictive value for short- and long-term clinical outcomes. 
  2. Characterize mucosal immune cells in different mucosal compartments segmented by code-free deep learning image analysis in IBD-patients stratified with histological indexing.
  3. Identify and characterize histopathological traits, genomic-/genetic-, immunological- and molecular mechanisms illuminating the underlying differences between IBD-patient subgroups based on stratification with histological indexing. 
  4. Use open-source software and tools for digital computational pathology and artificial intelligence (deep convolutional neural networks) to further develop models for automated image analysis of tissue sections. 
  5. Identify, characterize, and validate clinically relevant histopathological and immunohistochemical markers.

2.Genetics and Genomics Unit

In this unit, we explore how genes and gene expression in IBD patients differ from healthy controls. We are also interested in what gene variants and gene expression within the IBD patient cohort can tell us about each individual’s disease prognosis and treatment response.

We perform large genome and gene expression analyses of patient samples and patient-derived cell cultures and correlate these results with clinical observations identifying genes and processes that can be used clinically for improved, more precise treatment and diagnosis. Identified processes and gene variants are followed up to better understand the mechanisms underlying the observed difference. All studies are performed in close collaboration with the other units within CAG-IBD, as well as the clinic.

Objectives for ongoing research activities:

  1. Identify genetic variants that predispose for a complicated disease course and poor treatment outcome in IBD.
  2. Characterize the mechanisms underlying the effect of these genetic variants, for example through sequence variants in miRNA binding sites.
  3. Evaluate if the identified genetic variants are efficient and reproducible biomarkers for use in the clinic.
  4. Elucidate epithelial involvement in regulating the intestinal inflammation seen in IBD through gene expression analyses of epithelial cells from IBD patients and experiments in patient-derived epithelial cell lines.
  5. Characterize the role of serotonin and epithelial serotonin reuptake transporter in intestinal fibrosis.
  6. Investigate how epithelial regeneration is balanced in an inflamed intestinal environment.

3.Cell and Molecular Biology Unit

In this unit we explore microbiota-host interactions and IBD patient-derived ex vivo model systems for individual characteristics and differences in immunological and drug responses. We perform a range of advanced molecular analyses of patient material; and use state-of-the-art patient-derived models for functional studies to understand how interactions between microbiota, intestinal epithelium and immune cells disturb or contribute to inflammation, regeneration of the intestinal epithelium and mucosal healing in IBD. The work is performed in close collaborations with the other research units in the CAG-IBD.

Objectives for ongoing research activities:

  1. Characterize the presence and frequency of commensal and pathogenic microbiota (bacteria and viruses) in IBD patients for possible associations with disease remission or aggravation.
  2. Investigate signal transduction and cellular responses in patient-derived cells to understand how interactions between signals from microbiota (viruses, bacteria, fungi), intestinal epithelium and immune cells contribute to IBD pathobiology.
  3. Refine experimental platforms allowing co-cultures of intestinal cells, immune cells and microbiota; and use patient-specific material as tools in IBD-precision medicine.
  4.  Characterize organoids from a cohort of diseased including individuals with unique phenotypic or genetic variations to better understand IBD heterogeneity.
  5. Establish methods for genetic modification of patient-derived organoids.
  6. Use approved and investigational IBD-drugs to both gain insight about their modes of action, and as experimental tools to understand heterogeneity in treatment responses.
  7. Evaluate patient-derived organoids as drug testing platform and correlate with clinical outcome.

Link: https://www.ntnu.edu/cag-ibd/

Researcher from NTNU in CAG IBD:

Akershus universitetssykehus

Gastromedisinsk forskningsgruppe ved Akershus universitetssykehus

Gastromedisinsk forskningsgruppe er ledet av professor Jørgen Jahnsen. Gruppen består av 12 personer, åtte leger (en professor II, en 1.amanuensis, en postdoc, fem PhD-studenter) og fire studiesykepleiere.

Forskningsprofil

Størstedelen av forskningsaktiviteten er relater til inflammatorisk tarmsykdom (IBD), men det forskes også på cøliaki og leversykdommer. Vi er involvert i basalforskning, så vel som klinisk forskning og medikamentutprøving i diverse legemiddelstudier. I basalforskningen fokuserer vi på prognostiske faktorer for sykdomsforløp og behandlingseffekt, samt mekanismer bak utvikling av IBD-relatert tarmkreft. I kliniske studier ser vi på effekten av medikamentmålinger ved biologisk behandling, behandling med intravenøst jern, mikrobiotas rolle og ekstrakorporal fotoferese som fremtidig behandlingsmulighet.

Forskningsprosjekter – IBD-relaterte

  1. IBD-CHARACTER: A multi-modal integrated biomarker study (IBD-Character Consortium) funded by EU´s 7th Framework Program.
  2. NOR-DRUM: A NORwegian multicentre randomised controlled trial assessing the effectiveness of tailoring infliximab treatment by therapeutic DRUg Monitoring.
  3. Nor-vaC: Prospective, observational study to evaluate immunogenicity and safety following SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases receiving immunosuppressive therapy.
  4. Colorectal neoplasia in IBD: A prospective study comparing endoscopic surveillance with regular clinical follow-up.
  5. Photopheresis in the treatment of patients with Crohns’ disease using 5-aminolevulinic acid.
  6. Gut microbiota – its relation to clinical outcome and mucosal barrier functions in IBD.
  7. Clinical implementation and safety of high dose i.v. iron treatment in gastroenterology.
  8. IBSEN II: This is a multi-center study, including five hospitals in the Helse Sør-Øst region, which has included 321 adult and pediatric IBD patients and controls.
  9. IBSEN III: This is a multi-center study, including 20 hospitals in the Helse Sør-Øst region, with the aim to include 2400 adult and pediatric IBD patients and controls.
  10. Inflammatory bowel disease and persistent organic pollutants (POPs): A translational research approach.
  11. Molecular drivers and inhibitors of colorectal cancer in IBD. This project is a close collaboration with Hilde Nilsen group at EpiGen Institute Ahus. different stages of carcinogenesis in IBD.
  12. Identification of predictive biomarkers for personalised treatment of patients with Crohn’s disease. Single cell RNA sequencing (scRNAseq) and spatial transcriptomics.
  13. BLUE study: Incidence, treatment and outcome of gastrointestinal bleeding due to peptic ulcers and erosions.
  14. Clinical trials. The unit has a high activity in conducting clinical trials, both phase 2 and 3, initiated by the pharmaceutical industry to evaluate efficacy and safety for new medical treatments in IBD.

Leder: Jørgen Jahnsen, MD, PhD, professor og overlege, Akershus universitetssykehus Gastromedisinsk avdeling og UiO. E: jorgen.jahnsen@medisin.uio.no.

Akershus universitetssykehus

Barnegastroenterologisk forskningsgruppe ved Akershus universitetssykehus

Forskningsprofil

Barnegastroenterologisk forskningsgruppe arbeider med basalmedisinske og kliniske studier knyttet til mage-tarm- og tarmflora (mikrobiota). Hovedfokuset er inflammatorisk tarmsykdom (eng. IBD).

Interesseområder: Diagnostisering og karakterisering av IBD, prognose, skreddersydd behandling fra debut, biologisk behandling , ernæringsbehandling ved Crohns sykdom (EEN – eksklusiv enteral ernæring og CDED -Crohns Disease Exclusion Diet), tretthet og utmattelse (fatigue), og tarmfloraens (mikrobiomets) rolle.

Forskningsprosjekter – IBD-relaterte

Gruppen er engasjert i følgende studier:

  1. Mikrobiomet (tarmens bakterieflora) ved inflammatorisk tarmsykdom – sammenheng med diagnose, sykdomsaktivitet og sykdomsforløp. Postdoktor prosjekt sammen med Epigen på Ahus. “Human og mikrobiell crosstalk” hos pasienter med IBD. Vi ser på mikrobiota i feces og biopsier, både tilstedeværelse og gen ekspresjon/ funksjon.
  2. Mikrobiota ved COVID -19. ”Precision microbiota profiling of COVID-19 in adolescents. Focus on diagnosis, prognosis and long-term effects”. Vi ser på feces (samarbeid med BioME) og blodmikrobiomet, spesielt i forhold til utvikling av fatigue.

Samarbeidsprosjekter

  1. IBSEN III (Inflammatory Bowel Disease in South Eastern Norway)
  2. DOUBLE PIBD: Europeisk samarbeid om pediatriske IBD pasienter får dobbeltbehandling med to biologiske medikamenter
  3. VEOIBD: Europeisk samarbeid med genanalyser og undersøkelser av barn med tidlig debut av IBD.
  4. SPEED UP: Europeisk samarbeid, bruk av ustekinumab hos barn med IBD
  5. EURKIDS: Europeisk registerstudie av pediatrisk IBD
  6. EOSINOFIL ØSOFAGITT: Norsk pediatrisk samarbeid om diagnostikk og behandling av eosinofil øsofagitt
  7. Kognisjon og psykisk helse hos barn med Down og glutensensitivitet
  8. IBD Character EU multinational collaborative study

Leder: Christine Olbjørn, MD, PhD, postdoktor og overlege, Akershus Universitetssykehus, Barne og ungdomsklinikken. E: chrisolb@gmail.com.

 

Helse Stavanger - Stavanger Universitetssykehus

Gastroenterologisk forskningsgruppe ved Stavanger universitetssjukehus

Forskningsprofil

Gastroenterologisk forskningsgruppe arbeider med studier knyttet til mage-/tarm- og leversykdommer. Hovedfokuset er inflammatorisk tarmsykdom (eng. IBD).

Interesseområder: sykdomsutvikling og mekanismene bak dette, hva som kjennetegner pasienter som responderer godt på medisinsk behandling, biologisk behandling, tretthet og utmattelse (fatigue), tarmfloraens (mikrobiomets) rolle. Forskningen består av både basalmedisinske og kliniske studier.

Forskningsprosjekter – IBD-relaterte

Gruppen er engasjert i følgende studier:

  1. Stavanger Universitetssjukehus IBD studie (SUSI).
    Substudier/-prosjekter:
    – Fatigue ved inflammatorisk tarmsykdom.
    – Serumkonsentrasjonsmåling av infliximab og adalimumab ved IBD – effekt på sykdomsaktivitet, fatigue og livskvalitet.
    – Optimalisert biologisk behandling med infliximab ved akutt alvorlig ulcerøs kolitt.
    – Antistoffproduksjon mot biologisk medikament.
    – Mikrobiomet (tarmens bakterieflora) ved inflammatorisk tarmsykdom – sammenheng med sykdomsaktivitet og sykdomsforløp.

    Samarbeidsprosjekter:

  2. Blastocystis’ rolle ved inflammatorisk tarmsykdom.
  3. BIOSTOP-studien (seponering av biologisk behandling).
  4. NOR-DRUM-studien (Del A) (serumkonsentrasjon infliximab).
  5. SCAN-IBD studien (kolorektal cancer ved IBD).
  6. TITRATE studien (akutt alvorlig ulcerøs kolitt).
  7. SONORESCUE-studien (UL evaluering i akutt alvorlig ulcerøs kolitt).

Leder: Tore Grimstad, MD, PhD, overlege, førsteamanuensis Stavanger universitetssjukehus. E: tore.bjorn.grimstad@sus.no

Haukeland universitetssjukehus

Forskningsprofil Bergen/Haukeland Universitetssjukehus (HUS)

Gastroenterologisk seksjon på HUS har mange ulike forskningsgrupper med ulike interesseområder som bl.a fokuserer på irritabel tarm, bukspyttkjertel avansert endoskopi og inflammatorisk tarm (IBD).

Det er ingen egen forskningsgruppe for IBD ved HUS, men vi har forskningsprosjekter som inkluderer IBD-pasienter. Disse utgår i all hovedsak fra Nasjonalt kvalitets- og kompetansenettverk for gastroenterologisk ultralyd (NSGU: https://helse-bergen.no/nasjonalt-nettverk-for-gastroenterologisk-ultralyd) og Bergen Research Group for Ultrasound in Gastroenterology (BRUSE, https://www.uib.no/en/rg/ultrasound).

Interesseområder:

  • utvikling av nye ultralydmetoder
  • bruk av ultralyd i diagnostikk og for monitorering av IBD-behandling
  • bruk av pasientrapporterte symptomskårer i klinisk praksis.

Forskningsprosjekter – IBD-relaterte

Substudier/-prosjekter:

  • Ultralydundersøkelse av Ulcerøs kolitt i akutt fase og oppfølging etter at behandling er startet, Sonorescue.
  • Ultralyd med drikkekontrast hos pasienter med Crohns sykdom i overgangen mellom tykk-tynntarm, SonoDOCc.
  • Symptombaserte aktivitetsskårer for Crohns sykdom og Ulcerøs kolitt (Validering i en norsk IBD-populasjon)

Samarbeidsprosjekter:

BIOSTOP-studien (seponering av biologisk behandling).

USE-IT studien (Internasjonal multisenterstudie organisert av IBUS, Helmsley USE-IT project – IBUS – International Bowel Ultrasound Group (ibus-group.org)

Kontaktperson: Kim Nylund MD, PhD, overlege, førsteamanuensis Haukeland Universitetssjukehus.

Oslo Universitet Sykehus | Logo

Inflammatory bowel disease research group

The focus for the inflammatory bowel disease (IBD) research group is clinical epidemiology, prognostic research and patient-reported outcomes research within IBD (Crohn’s disease and ulcerative colitis).

We organise and conduct large population-based cohort studies as well as local interventional and quality studies, and we use nationwide patient registries. 

The IBD research group has a strong clinical affiliation and a broad network of collaborators in several research fields including epidemiology, health economy, biostatistics and medical informatics, patient reported outcomes research, study of the microbiome, genetics and nutrition.

Over the last years we have had a special interest in the changes in IBD treatment patterns, including the introduction and use of new targeted therapies at local, regional and national level.

Research project overview

IBD forskningsgruppen gruppebilde
Marte Lie Høivik

Marte Lie Høivik

Overlege, Professor, PhD
Oslo universitetssykehus, Ullevål

Ann Elisabeth Østvik

Ann Elisabeth Østvik

Overlege, Førsteamanuensis, Phd St. Olavs hospital og NTNU

Ignacio Catalán-Serra

Ignacio Catalán-Serra

Overlege, PhD
Levanger sykehus og NTNU

Hilde L von Volkmann

Overlege, PhD
Haukeland universitetssjukehus

Petr Ricanek

Petr Ricanek

Overlege, PhD
Lovisenberg Diakonale Sykehus

Christine Olbjørn

Christine Olbjørn

Overlege, PhD
Akershus universitetssykehus

Tore Grimstad

Overlege, Førsteamanuensis, PhD Stavanger universitetssjukehus

8. Behandling Crohns sykdom

Tore Grimstad, MD, PhD, overlege og førsteamanuensis, Stavanger universitetssjukehus.

Tar for seg behandlingsmål ved Crohns sykdom og gir en omfattende oversikt over symptomatisk, medikamentell- (inkludert konvensjonell og biologisk behandling) og kirurgisk behandling.

7. Behandling ulcerøs kolitt

Hilde Løland von Volkmann, MD, PhD, overlege, Haukeland universitetssjukehus.

Her gis en oversikt over behandling ved ulcerøs kolitt (avhengig av grad av utbredelse og inflammasjon), både lokalbehandling, systemisk, biologisk og kirurgisk.

6. Pediatrisk IBD

Christine Olbjørn, MD, PhD, overlege, barne og ungdomsklinikken, Akershus universitetssykehus.

Oversikt over hva som er annerledes hos barn med IBD, assosierte sykdommer som orofacial granulomatose, differensialdiagnoser, utredning og behandling, inkludert ernæringsterapi med eksklusiv enteral ernæring.

5. Utredning Crohns sykdom

Petr Ricanek, MD, PhD, overlege, Akershus universitetssykehus.

Foredraget forklarer hva Crohns er, og gir oversikt over utredning, klassifikasjon/fenotyper og prognostiske faktorer.

4. Utredning ulcerøs kolitt​

Hilde Løland von Volkmann, MD, PhD, overlege, Haukeland universitetssjukehus.

Omhandler symptomer, differensialdiagnoser, utredning og klassifisering av ulcerøs kolitt.

3. Kliniske manifestasjoner IBD

Ignacio Catalán- Serra, MD, PhD, overlege, Levanger sjukehus.

Tar for seg symptomer ved Crohns sykdom og ulcerøs kolitt, (felles og spesifikke) komplikasjoner og ekstraintestinale manifestasjoner.

2. Patofysiologi IBD

Ann Elisabet Østvik, MD, PhD, overlege og førsteamanuensis, St Olavs hospital

Foredraget går gjennom epidemiologi, miljøfaktorer, tarmflora, genetikk og immunresponser ved IBD.

1. Epidemiologi IBD

Marte Lie Høivik, overlege og førsteamanuensis, Oslo universitetssykehset Ullevål.

Foredraget går gjennom epidemiologiske aspekter ved inflammatorisk tarmsykdom.